Genetic Variant & Longevity Risk Explorer

Interpret your raw DNA SNPs (from 23andMe, Ancestry, or Whole Genome Sequencing). Check clinical significance, APOE4 Alzheimer\'s risk, MTHFR methylation, ACTN3 muscle fibers, and COMT dopamine dynamics.

Featured Biomarkers (5)

rs429358Gene: APOE

Apolipoprotein E4 (Alzheimer's & Lipid Cardiovascular Risk)

Chr 19: 44908684 (GRCh38)

ClinVar: Risk Factor

Human Chromosome #19 Genomic Locus MapChr 19: 44908684 (GRCh38)

p-arm (Telomere)Centromereq-arm (Telomere)

Select Your Raw DNA Genotype:From 23andMe / Ancestry

Risk Index: 25 / 100

Typical / Average

APOE-epsilon3 / epsilon3 (Neutral Baseline)

Standard baseline population risk for cardiovascular disease and late-onset Alzheimer's disease.

Actionable Lifestyle & Nutritional Protocols

Maintain standard Zone 2 cardiovascular exercise (150 min/week).
Follow a Mediterranean-style whole-food diet rich in polyphenols and omega-3s.
Standard annual ApoB and lipid profile monitoring.

Global Risk Allele Frequency (gnomAD Multi-Population Distribution)

European15%

African26%

East Asian9%

South Asian11%

Molecular Mechanism

APOE encodes a glycoprotein that catabolizes triglyceride-rich lipoprotein constituents. The E4 isoform (Arg112) alters protein domain interaction, reducing amyloid-beta clearance and increasing blood-brain barrier permeability.

Read the Complete Genetic Longevity Masterclass

Deep dive into APOE4 lipid kinetics, MTHFR methylation biochemistry, and ACTN3 power athletics.

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Genomics & Medical Disclaimer:Genetic variant associations are retrieved from the National Center for Biotechnology Information (NCBI dbSNP, ClinVar) and gnomAD databases for informational purposes. Single Nucleotide Polymorphisms (SNPs) represent statistical correlations and probabilistic risk modifiers, not definitive clinical diagnoses. Consult a board-certified medical geneticist or genetic counselor for clinical interpretation.

Tools Health & LongevityGenetic Variant Explorer

ClinVar, dbSNP & gnomAD Genomic Data Connected