Drug Target & Bioactive Molecule Explorer

Explore how pharmaceutical medications bind human cellular receptors and enzymes. Inspect nanomolar binding potencies (IC50 / Ki), Open Targets disease associations, and sigmoidal dose-response kinetics.

Featured Drug Targets (5)

GLP1RCHEMBL1784

Glucagon-Like Peptide 1 Receptor

Class B G-Protein Coupled Receptor (GPCR)

Open Targets: 0.98 / 1.00

Sigmoidal Dose-Response Binding Curve: Semaglutide (Ozempic/Wegovy)

IC50 Potency: 0.38 nM

Simulated Drug Plasma Concentration:1.00 nM

Receptor Target Occupancy / Inhibition:72.5%

Molecular Function & Physiological Role

Stimulates glucose-dependent insulin secretion from pancreatic beta cells, inhibits glucagon secretion, and signals central hypothalamic satiety circuits.

Therapeutic Ligands & Nanomolar Potency (IC50 / Ki)

Primary Clinical Disease Indications

Type 2 Diabetes MellitusObesity & Chronic Weight ManagementCardiovascular Risk Reduction (MACE)

Biological Signal Transduction Pathway

Incretin hormone receptor signaling pathway via Gs-alpha adenylate cyclase activation, elevating intracellular cAMP and protein kinase A (PKA).

Primary Pharmacology Databases

ChEMBL Target Card (CHEMBL1784)Open Targets Genetics Profile

Read the Pharmacology & IC50 Masterclass

Deep dive into Cheng-Prusoff binding thermodynamics, ChEMBL screening, and receptor pharmacology.

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Pharmacology & Bioactivity Notice:Bioactivity values (IC50, Ki, Kd) and target disease associations are retrieved from the ChEMBL database (EMBL-EBI) and Open Targets Platform. This tool is designed for educational, academic, and pharmacological research purposes only.

Tools Health & LongevityDrug Target & Receptor Explorer

ChEMBL Database (EMBL-EBI) & Open Targets Platform Connected