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Human InsulinPDB: 1TRZ

Homo sapiens (Human) • UniProt: P01308

3D Real-Time Render: 48 Residue Nodes

AlphaFold pLDDT Structural Confidence SpectrumMean: 94.6 / 100

Very High (pLDDT > 90) (82%)

Confident (70-90) (14%)

Low / Flexible (50-70) (4%)

Disordered (< 50) (0%)

Sequence Length

110 AAs

Experimental Resolution

1.50 Å (X-Ray Diffraction)

Alpha-Helices

58%

Beta-Sheets

Biological Role & Mechanism

Crucial endocrine hormone regulating carbohydrate and lipid metabolism. Synthesized as preproinsulin, cleaved into A and B chains linked by two interchain disulfide bonds (A7-B7 and A20-B19) and one intrachain bridge (A6-A11).

Key Catalytic & Structural Residues

Cys7 (A-Chain)Position #7

Forms critical interchain disulfide bond with Cys7 of B-chain

Cys19 (B-Chain)Position #19

Forms structural stabilizing disulfide bridge with Cys20 of A-chain

Phe24 (B-Chain)Position #24

Key aromatic residue essential for Insulin Receptor (INSR) binding

Primary Structural Repositories

AlphaFold Database Entry RCSB PDB Structure (1TRZ)UniProtKB Functional Record

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Structural Biology & Attribution Notice:Predicted protein coordinates and per-residue confidence scores are generated by DeepMind\'s AlphaFold AI system in partnership with EMBL-EBI. Experimental coordinates are deposited in the Worldwide Protein Data Bank (wwPDB).

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